Forensic Microscope
Welcome to Forensic MicroscopeDevelopment of antiviral agents for enteroviruses
Development of antiviral agents for enteroviruses
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Enteroviruses (EVs) are common human pathogens that are associated with numerous disease symptoms in many organ systems of the body. Although EV infections commonly cause mild or non-symptomatic illness, some of them are associated with severe diseases such as CNS complications. The current absence of effective vaccines for most viral infection and no available antiviral drugs for the treatment of EVs highlight the urgency and significance of developing antiviral agents. Several key steps in the viral life cycle are potential targets for blocking viral replication. This article reviews recent studies of antiviral developments for EVs based on various molecular targets that interrupt viral attachment, viral translation, polyprotein processing and RNA replication.
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| • | Thanks to Reviewers |
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| • | social network, ghosts, UFO, aliens |
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| • | Common Cold Virus Came From Birds About 200 Years Ago, Study Suggests |
| A virus that causes cold-like symptoms in humans originated in birds and may have crossed the species barrier around 200 years ago, according to an article in the Journal of General Virology. Scientists hope their findings will help us understand how potentially deadly viruses emerge in humans. |
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| • | Effects of pre-commercial thinning on transpiration in young post-fire maritime pine stands |
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In the present study, the effect of heavy thinning on soil water content was investigated in relation to water use in an 8-year-old post-fire-regenerated maritime pine (Pinus pinaster Ait.) stand in northwestern Spain over two growing seasons. Three different treatment levels were selected: control (unthinned, 40 200 saplings ha–1), intense thinning (leaving 3850 saplings ha–1) and very intense thinning (leaving 1925 saplings ha–1); sap flow measurements were made on 10 saplings in each treatment throughout two growing seasons following thinning. Soil water availability in thinned plots was 1.8 times higher in the first growing season and 2.5 times higher in the second season, than in the control plots. Sap flow density in very intensely thinned plots was lower than in the control plots 3–5 months after treatment. However, for the whole study period the mean sap flow density in saplings was higher in thinned plots than in unthinned plots (about double in the first growing season and 1.7 times higher in the second). Monthly transpiration at plot level was 8.8 and 4.4 times higher in control plots, than in very intensely and intensely thinned plots, respectively, in the first growing season, and 4.5 and 2.8 in the second season. Very intense thinning did not result in significant differences in saplings sap flow and transpiration at plot level, compared with intense thinning. Some consequences of these results for the management of such juvenile stands are discussed. |
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| • | To treat a minor wound |
| Treatment for a wound causing slight bleeding | |
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